Effects of Armodafinil and Cognitive Behavior Therapy for Insomnia on Sleep Continuity and Daytime Sleepiness in Cancer Survivors
Identifieur interne : 001E57 ( Main/Exploration ); précédent : 001E56; suivant : 001E58Effects of Armodafinil and Cognitive Behavior Therapy for Insomnia on Sleep Continuity and Daytime Sleepiness in Cancer Survivors
Auteurs : Sheila N. Garland [États-Unis] ; Joseph A. Roscoe [États-Unis] ; Charles E. Heckler [États-Unis] ; Holly Barilla [États-Unis] ; Philip Gehrman [États-Unis] ; James C. Findley [États-Unis] ; Anita R. Peoples [États-Unis] ; Gary R. Morrow [États-Unis] ; Charles Kamen [États-Unis] ; Michael L. Perlis [États-Unis]Source :
- Sleep medicine [ 1389-9457 ] ; 2015.
Abstract
This study involves the analysis of a secondary outcome of a trial examining whether cognitive behavior therapy for insomnia (CBT-I), a wake-promoting medication (armodafinil), or both results in greater improvement in prospectively assessed sleep continuity and daytime sleepiness than a placebo-alone group among a heterogeneous group of cancer survivors. Whether or not armodafinil alone, and/or when combined with CBT-I, affected adherence with CBT-I was evaluated.
This study is a randomized, placebo-controlled, clinical trial.
This study was conducted at two northeastern academic medical centers.
Eighty-eight cancer survivors with chronic insomnia were recruited between October 2008 and November 2012. Participants were assigned to one of four conditions: 1) CBT-I and placebo (CBTI+P); 2) CBT-I and armodafinil (CBT-I+A); 2) armodafinil alone (ARM); or 4) placebo alone (PLA).
CBT-I was delivered in seven weekly individual therapy sessions (three in person, four via telephone). The armodafinil dosage was 50 mg BID.
Sleep continuity was measured with daily sleep diaries assessing sleep latency (SL), wake after sleep onset (WASO), and total sleep time (TST). The Epworth Sleepiness Scale (ESS) measured daytime sleepiness. Compared to the PLA group, the CBT+P and CBT+A groups reported a significant reduction in SL with effect sizes of 0.67 and 0.58, respectively. A significant reduction was observed in WASO in the CBT+A group with an effect size of 0.64. An increasing trend of TST was observed in the CBT+P, CBT+A, and PLA groups, but not in the ARM group. No statistically significant reductions in daytime sleepiness (ESS) were observed for any of the groups.
CBT-I alone and in combination with armodafinil caused significant improvement in sleep continuity. The addition of armodafinil did not appear to improve daytime sleepiness or enhance adherence to CBT-I.
Url:
DOI: 10.1016/j.sleep.2015.12.010
PubMed: 27318221
PubMed Central: 5267578
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 003433
- to stream Pmc, to step Curation: 003432
- to stream Pmc, to step Checkpoint: 001312
- to stream Ncbi, to step Merge: 008451
- to stream Ncbi, to step Curation: 008451
- to stream Ncbi, to step Checkpoint: 008451
- to stream Main, to step Merge: 001E60
- to stream Main, to step Curation: 001E57
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of Armodafinil and Cognitive Behavior Therapy for Insomnia on Sleep Continuity and Daytime Sleepiness in Cancer Survivors</title>
<author><name sortKey="Garland, Sheila N" sort="Garland, Sheila N" uniqKey="Garland S" first="Sheila N." last="Garland">Sheila N. Garland</name>
<affiliation wicri:level="1"><nlm:aff id="A1">University of Pennsylvania, Department of Family Medicine and Community Health, 3400 Spruce Street, Philadelphia, PA, 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pennsylvania, Department of Family Medicine and Community Health, 3400 Spruce Street, Philadelphia, PA, 19104</wicri:regionArea>
<wicri:noRegion>19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">University of Pennsylvania, Abramson Cancer Center, 3400 Civic Center Blvd, Philadelphia, PA, 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pennsylvania, Abramson Cancer Center, 3400 Civic Center Blvd, Philadelphia, PA, 19104</wicri:regionArea>
<wicri:noRegion>19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104</wicri:regionArea>
<wicri:noRegion>PA 19104</wicri:noRegion>
</affiliation>
<affiliation><nlm:aff id="A5">Memorial University of Newfoundland, Department of Psychology, 232 Elizabeth Avenue, St. John’s NL, Canada. A1B 3X9</nlm:aff>
<wicri:noCountry code="subfield">Canada. A1B 3X9</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Roscoe, Joseph A" sort="Roscoe, Joseph A" uniqKey="Roscoe J" first="Joseph A." last="Roscoe">Joseph A. Roscoe</name>
<affiliation wicri:level="1"><nlm:aff id="A4">University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642</wicri:regionArea>
<wicri:noRegion>NY 14642</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Heckler, Charles E" sort="Heckler, Charles E" uniqKey="Heckler C" first="Charles E." last="Heckler">Charles E. Heckler</name>
<affiliation wicri:level="1"><nlm:aff id="A4">University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642</wicri:regionArea>
<wicri:noRegion>NY 14642</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barilla, Holly" sort="Barilla, Holly" uniqKey="Barilla H" first="Holly" last="Barilla">Holly Barilla</name>
<affiliation wicri:level="1"><nlm:aff id="A3">University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104</wicri:regionArea>
<wicri:noRegion>PA 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gehrman, Philip" sort="Gehrman, Philip" uniqKey="Gehrman P" first="Philip" last="Gehrman">Philip Gehrman</name>
<affiliation wicri:level="1"><nlm:aff id="A3">University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104</wicri:regionArea>
<wicri:noRegion>PA 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Findley, James C" sort="Findley, James C" uniqKey="Findley J" first="James C." last="Findley">James C. Findley</name>
<affiliation wicri:level="1"><nlm:aff id="A3">University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104</wicri:regionArea>
<wicri:noRegion>PA 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peoples, Anita R" sort="Peoples, Anita R" uniqKey="Peoples A" first="Anita R." last="Peoples">Anita R. Peoples</name>
<affiliation wicri:level="1"><nlm:aff id="A4">University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642</wicri:regionArea>
<wicri:noRegion>NY 14642</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morrow, Gary R" sort="Morrow, Gary R" uniqKey="Morrow G" first="Gary R." last="Morrow">Gary R. Morrow</name>
<affiliation wicri:level="1"><nlm:aff id="A4">University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642</wicri:regionArea>
<wicri:noRegion>NY 14642</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kamen, Charles" sort="Kamen, Charles" uniqKey="Kamen C" first="Charles" last="Kamen">Charles Kamen</name>
<affiliation wicri:level="1"><nlm:aff id="A4">University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642</wicri:regionArea>
<wicri:noRegion>NY 14642</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perlis, Michael L" sort="Perlis, Michael L" uniqKey="Perlis M" first="Michael L." last="Perlis">Michael L. Perlis</name>
<affiliation wicri:level="1"><nlm:aff id="A3">University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104</wicri:regionArea>
<wicri:noRegion>PA 19104</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27318221</idno>
<idno type="pmc">5267578</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267578</idno>
<idno type="RBID">PMC:5267578</idno>
<idno type="doi">10.1016/j.sleep.2015.12.010</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">003433</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003433</idno>
<idno type="wicri:Area/Pmc/Curation">003432</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003432</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001312</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001312</idno>
<idno type="wicri:Area/Ncbi/Merge">008451</idno>
<idno type="wicri:Area/Ncbi/Curation">008451</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">008451</idno>
<idno type="wicri:doubleKey">1389-9457:2015:Garland S:effects:of:armodafinil</idno>
<idno type="wicri:Area/Main/Merge">001E60</idno>
<idno type="wicri:Area/Main/Curation">001E57</idno>
<idno type="wicri:Area/Main/Exploration">001E57</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of Armodafinil and Cognitive Behavior Therapy for Insomnia on Sleep Continuity and Daytime Sleepiness in Cancer Survivors</title>
<author><name sortKey="Garland, Sheila N" sort="Garland, Sheila N" uniqKey="Garland S" first="Sheila N." last="Garland">Sheila N. Garland</name>
<affiliation wicri:level="1"><nlm:aff id="A1">University of Pennsylvania, Department of Family Medicine and Community Health, 3400 Spruce Street, Philadelphia, PA, 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pennsylvania, Department of Family Medicine and Community Health, 3400 Spruce Street, Philadelphia, PA, 19104</wicri:regionArea>
<wicri:noRegion>19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">University of Pennsylvania, Abramson Cancer Center, 3400 Civic Center Blvd, Philadelphia, PA, 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pennsylvania, Abramson Cancer Center, 3400 Civic Center Blvd, Philadelphia, PA, 19104</wicri:regionArea>
<wicri:noRegion>19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104</wicri:regionArea>
<wicri:noRegion>PA 19104</wicri:noRegion>
</affiliation>
<affiliation><nlm:aff id="A5">Memorial University of Newfoundland, Department of Psychology, 232 Elizabeth Avenue, St. John’s NL, Canada. A1B 3X9</nlm:aff>
<wicri:noCountry code="subfield">Canada. A1B 3X9</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Roscoe, Joseph A" sort="Roscoe, Joseph A" uniqKey="Roscoe J" first="Joseph A." last="Roscoe">Joseph A. Roscoe</name>
<affiliation wicri:level="1"><nlm:aff id="A4">University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642</wicri:regionArea>
<wicri:noRegion>NY 14642</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Heckler, Charles E" sort="Heckler, Charles E" uniqKey="Heckler C" first="Charles E." last="Heckler">Charles E. Heckler</name>
<affiliation wicri:level="1"><nlm:aff id="A4">University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642</wicri:regionArea>
<wicri:noRegion>NY 14642</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barilla, Holly" sort="Barilla, Holly" uniqKey="Barilla H" first="Holly" last="Barilla">Holly Barilla</name>
<affiliation wicri:level="1"><nlm:aff id="A3">University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104</wicri:regionArea>
<wicri:noRegion>PA 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gehrman, Philip" sort="Gehrman, Philip" uniqKey="Gehrman P" first="Philip" last="Gehrman">Philip Gehrman</name>
<affiliation wicri:level="1"><nlm:aff id="A3">University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104</wicri:regionArea>
<wicri:noRegion>PA 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Findley, James C" sort="Findley, James C" uniqKey="Findley J" first="James C." last="Findley">James C. Findley</name>
<affiliation wicri:level="1"><nlm:aff id="A3">University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104</wicri:regionArea>
<wicri:noRegion>PA 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peoples, Anita R" sort="Peoples, Anita R" uniqKey="Peoples A" first="Anita R." last="Peoples">Anita R. Peoples</name>
<affiliation wicri:level="1"><nlm:aff id="A4">University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642</wicri:regionArea>
<wicri:noRegion>NY 14642</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morrow, Gary R" sort="Morrow, Gary R" uniqKey="Morrow G" first="Gary R." last="Morrow">Gary R. Morrow</name>
<affiliation wicri:level="1"><nlm:aff id="A4">University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642</wicri:regionArea>
<wicri:noRegion>NY 14642</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kamen, Charles" sort="Kamen, Charles" uniqKey="Kamen C" first="Charles" last="Kamen">Charles Kamen</name>
<affiliation wicri:level="1"><nlm:aff id="A4">University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Rochester, James P. Wilmot Cancer Center, 265 Crittenden Blvd. CU 420658, Rochester, NY 14642</wicri:regionArea>
<wicri:noRegion>NY 14642</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perlis, Michael L" sort="Perlis, Michael L" uniqKey="Perlis M" first="Michael L." last="Perlis">Michael L. Perlis</name>
<affiliation wicri:level="1"><nlm:aff id="A3">University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pennsylvania, Department of Psychiatry, Behavioral Sleep Medicine Program, 3535 Market Street, Suite 670, Philadelphia, PA 19104</wicri:regionArea>
<wicri:noRegion>PA 19104</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Sleep medicine</title>
<idno type="ISSN">1389-9457</idno>
<idno type="eISSN">1878-5506</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Study Objectives</title>
<p id="P1">This study involves the analysis of a secondary outcome of a trial examining whether cognitive behavior therapy for insomnia (CBT-I), a wake-promoting medication (armodafinil), or both results in greater improvement in prospectively assessed sleep continuity and daytime sleepiness than a placebo-alone group among a heterogeneous group of cancer survivors. Whether or not armodafinil alone, and/or when combined with CBT-I, affected adherence with CBT-I was evaluated.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P2">This study is a randomized, placebo-controlled, clinical trial.</p>
</sec>
<sec id="S3"><title>Setting</title>
<p id="P3">This study was conducted at two northeastern academic medical centers.</p>
</sec>
<sec id="S4"><title>Participants</title>
<p id="P4">Eighty-eight cancer survivors with chronic insomnia were recruited between October 2008 and November 2012. Participants were assigned to one of four conditions: 1) CBT-I and placebo (CBTI+P); 2) CBT-I and armodafinil (CBT-I+A); 2) armodafinil alone (ARM); or 4) placebo alone (PLA).</p>
</sec>
<sec id="S5"><title>Interventions</title>
<p id="P5">CBT-I was delivered in seven weekly individual therapy sessions (three in person, four via telephone). The armodafinil dosage was 50 mg BID.</p>
</sec>
<sec id="S6"><title>Measurements and Results</title>
<p id="P6">Sleep continuity was measured with daily sleep diaries assessing sleep latency (SL), wake after sleep onset (WASO), and total sleep time (TST). The Epworth Sleepiness Scale (ESS) measured daytime sleepiness. Compared to the PLA group, the CBT+P and CBT+A groups reported a significant reduction in SL with effect sizes of 0.67 and 0.58, respectively. A significant reduction was observed in WASO in the CBT+A group with an effect size of 0.64. An increasing trend of TST was observed in the CBT+P, CBT+A, and PLA groups, but not in the ARM group. No statistically significant reductions in daytime sleepiness (ESS) were observed for any of the groups.</p>
</sec>
<sec id="S7"><title>Conclusion</title>
<p id="P7">CBT-I alone and in combination with armodafinil caused significant improvement in sleep continuity. The addition of armodafinil did not appear to improve daytime sleepiness or enhance adherence to CBT-I.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Garland, Sheila N" sort="Garland, Sheila N" uniqKey="Garland S" first="Sheila N." last="Garland">Sheila N. Garland</name>
</noRegion>
<name sortKey="Barilla, Holly" sort="Barilla, Holly" uniqKey="Barilla H" first="Holly" last="Barilla">Holly Barilla</name>
<name sortKey="Findley, James C" sort="Findley, James C" uniqKey="Findley J" first="James C." last="Findley">James C. Findley</name>
<name sortKey="Garland, Sheila N" sort="Garland, Sheila N" uniqKey="Garland S" first="Sheila N." last="Garland">Sheila N. Garland</name>
<name sortKey="Garland, Sheila N" sort="Garland, Sheila N" uniqKey="Garland S" first="Sheila N." last="Garland">Sheila N. Garland</name>
<name sortKey="Gehrman, Philip" sort="Gehrman, Philip" uniqKey="Gehrman P" first="Philip" last="Gehrman">Philip Gehrman</name>
<name sortKey="Heckler, Charles E" sort="Heckler, Charles E" uniqKey="Heckler C" first="Charles E." last="Heckler">Charles E. Heckler</name>
<name sortKey="Kamen, Charles" sort="Kamen, Charles" uniqKey="Kamen C" first="Charles" last="Kamen">Charles Kamen</name>
<name sortKey="Morrow, Gary R" sort="Morrow, Gary R" uniqKey="Morrow G" first="Gary R." last="Morrow">Gary R. Morrow</name>
<name sortKey="Peoples, Anita R" sort="Peoples, Anita R" uniqKey="Peoples A" first="Anita R." last="Peoples">Anita R. Peoples</name>
<name sortKey="Perlis, Michael L" sort="Perlis, Michael L" uniqKey="Perlis M" first="Michael L." last="Perlis">Michael L. Perlis</name>
<name sortKey="Roscoe, Joseph A" sort="Roscoe, Joseph A" uniqKey="Roscoe J" first="Joseph A." last="Roscoe">Joseph A. Roscoe</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E57 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E57 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:5267578 |texte= Effects of Armodafinil and Cognitive Behavior Therapy for Insomnia on Sleep Continuity and Daytime Sleepiness in Cancer Survivors }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27318221" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |